AMG-36

AMG-36 (part of theAM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8 – THC substituted with a cyclopentane group on the 3-position sidechain. AMG-36 is a potent agonist at both CB1 and CB2 withmoderate selectivity for CB1, with a Ki of 0.45 nM at CB1 vs1.92 nM at CB2. / AMG-36 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ 8 – THC substituted with a cyclopentane group on the 3-position side chain.
CAS Number: 579444-43-2
Formula: C₂₇H₄₀O₂
Molar mass: 396.615 g·mol−1

AMG-36 is an analgesic drug that belongs to the cannabinoid agonist class. It is derived from Δ8-THC (tetrahydrocannabinol) and features a cyclopentane group substitution on the 3-position side chain. Here are some key details about AMG-36:

• Chemical Formula: C₂₇H₄₀O₂
• Molar Mass: 396.615 g/mol
• Structure:
• Agonist Activity:
  • Potent agonist at both CB₁ and CB₂ receptors.
  • Moderate selectivity for CB₁ (Kᵢ = 0.45 nM at CB₁) compared to CB₂ (Kᵢ = 1.92 nM at CB₂).

AMG-36 is part of the AM cannabinoid series and exhibits analgesic properties. Its unique structure and interaction with cannabinoid receptors make it an interesting compound in the field of pharmacology.