AMG-3

AMG-3 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8- THC substituted with a dithiolane group on the 3-position sidechain. AMG-3 is a potent agonist at both CB1 and CB2 receptors with a Ki of 0.32 nM at CB1 and 0.52 nM at CB2, and its particularly high binding affinity has led to it being usedas a template for further structural development of novelcannabinoid drugs.It has sedative and analgesic effects, withanalgesia lasting for up to 36 hours after administration. MG-3 is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ⁸-THC substituted with a dithiolane group on the 3-position side chain. Wikipedia
ChemSpider ID: 8178532
ChEMBL Id: 476325

AMG-3 is an analgesic drug that belongs to the cannabinoid agonist class. It is derived from Δ8-THC and features a dithiolane group substitution on the 3-position side chain. This compound exhibits potent agonism at both CB1 and CB2 receptors, with a binding affinity of 0.32 nM at CB1 and 0.52 nM at CB2. Its remarkable binding affinity has made it a template for developing novel cannabinoid drugs. Notably, AMG-3 has sedative and analgesic effects, with analgesia lasting up to 36 hours after administration.

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