JWH-138

JWH-138 (THC-Octyl, Δ8-THC-C8) is a synthetic cannabinoid first synthesised by John W. Huffman, with a Ki of 8.5nM at the CB1 cannabinoid receptor. JWH-018 substance has no known legitimate use outside of research and is purposely spiked on plant material. It has been identified in numerous herbal incense products including “Spice”, “K2”, and other similar products which are smoked for their psychoactive effects. CAS Number431041-39-3
PubChem CID102024084
FormulaC₂₄H₃₆O₂
Molar mass356.550 g·mol⁻¹

JWH-138, also known as THC-Octyl or Δ8-THC-C8, is a synthetic cannabinoid. Let’s delve into its properties and mechanisms:

Chemical Structure:
JWH-138 has the following IUPAC name: (6aR,10aR)-6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-octyl-6H-Dibenzo [b,d]pyran-1-ol.
Its chemical formula is C24H36O2, with a molar mass of 356.550 g/mol1.
Binding Affinity:
JWH-138 exhibits a high binding affinity (Ki value of 8.5nM) for the CB1 cannabinoid receptor1.
This receptor is part of the endocannabinoid system and plays a crucial role in regulating various physiological processes.
Historical Context:
JWH-138 was first synthesized by John W. Huffman.
Interestingly, its hydrogenated analog, HHC-Octyl, was studied by Roger Adams as early as 1942.
The alternate isomer, Δ9-THC-C8, has also been synthesized1.
Both the Δ8 and Δ9 isomers fall under the definition of an “intoxicating cannabinoid” in Colorado, where they are known as tetrahydrocannabioctyl.
Potency and Effects:
JWH-138 is a synthetic compound, and its effects are not well-documented.
It is part of the diverse family of cannabinoids, each with unique properties.
While some cannabinoids, like THC-O, are highly potent and psychedelic, others may have different effects2.
In summary, JWH-138 is a synthetic cannabinoid with binding affinity for the CB1 receptor, but its specific effects and potency remain less explored compared to other cannabinoids. As with any substance, caution and further research are essential when considering its use.