JWH-120

JWH-120
Legal status US : Schedule I
Identifiers IUPAC name (4-Methyl-1-naphthalenyl)(1-propyl-1H-indol-3-yl)methanone
CAS Number 824955-98-8 / JWH-120 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-propyl analog of JWH-122. It is a potent and selective ligand for the CB₂ receptor, but a weaker ligand for the CB₁ receptor. It has a binding affinity of Ki = 6.1 ± 0.7 nM at the CB2 subtype and 173 times selectivity over the CB1 subtype.[1] In the United States, all CB1 receptor agonists of the 3-(1naphthoyl)indole class such as JWH-120 are Schedule I Controlled Substances.

JWH-120 is a synthetic cannabimimetic compound discovered by John W. Huffman. It serves as the N-propyl analog of another compound called JWH-122. Here are some key details about JWH-120:

Chemical Formula: C₂₃H₂₁NO
Molar Mass: 327.427 g/mol
Binding Affinity:
CB₂ Receptor: Kᵢ = 6.1 ± 0.7 nM
CB₁ Receptor: Weaker ligand compared to CB₂
Legal Status in the United States: JWH-120, along with other CB₁ receptor agonists of the 3-(1-naphthoyl)indole class, is classified as a Schedule I Controlled Substance1.
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