JWH-018(China_JS-PC)

MANUFACTURER

Jiangsu Pharmaceutical Co., Ltd.
Address: 5th, 8th, 10th, 11th and 15th floors, Jinying Building, No. 258, Zhongyang Road, Xuanwu District, Nanjing City
Postal code: 210009

JWH-018(China_JS-PC) (CAS Num 209414-07-3)

JWH-018 is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂.
Formula: C24H23NO
Molar mass: 341.45 g/mol
Routes of administration: Smoked, Oral

JWH-018 produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products that in some countries are sold legally as “incense blends”./ JWH-018 is a synthetic cannabinoid receptor agonist with a strong affinity for the CB1 and CB2 receptors (EC50 = 102 nM and 133 nM, respectively)1. Binding to the receptors triggers a reduction of intracellular cAMP levels by inhibition of adenylate cyclase. In vivo studies on experimental mouse models showed similar responses as THC, including hypothermia, catalepsy, and hypolocomotor effects2.
In vitro, JWH-018 impaired electrically-induced synaptic transmission as well as LTP and glutamate/GABA release in ex vivo hippocampal slices. All behavioural and neurochemical effects could be prevented by pre-treatment with a CB1 receptor antagonist3.